A recent real-world study has demonstrated that combining the investigational Cuticapil stem cell hair serum with topical minoxidil significantly improves hair loss symptoms in patients with mild to moderate androgenetic alopecia and female pattern hair loss. The combined treatment promoted hair growth, reduced hair loss, and increased hair density.
Overview of the Study Design and Participants
This multicenter, prospective, parallel-group observational study involved 60 adult patients—18 men and 42 women—across seven clinics in Delhi, Mumbai, and Pune, India. The study was conducted between August 2023 and July 2024. The average age of participants was 34.18 years.
Patients were clinically diagnosed with male androgenetic alopecia (grades III to V) or female pattern hair loss (grades II or III). All had experienced hair thinning for more than six months, confirmed by a greater than 20% difference in hair diameter measured under a trichoscope. Among the male participants, 76.92% had grade III alopecia, while 84.75% of the female participants had grade II hair loss.
Treatment Protocol and Evaluation Methods
Some patients had prior experience using 2% minoxidil, while others were new to the treatment. Participants were randomly assigned to two groups: one group received both Stem Cell Hair Serum and Minoxidil Lotion, and the other received minoxidil alone. Both treatments were applied twice daily at a dose of 1 ml. Additionally, patients mixed the Stem Cell Hair Serum with a ketoconazole-free shampoo.
The researchers evaluated treatment effects after 12 weeks. They used a hair pull test, a holistic 7-point photographic analysis, and hair loss counts. Safety and patient satisfaction were also assessed through patient global evaluations.
Composition and Mechanism of Cuticapil Serum
Cuticapil serum contains a unique blend of active ingredients designed to work together for hair health. These include:
-
Caffeine Herbasome (green coffee bean and niacinamide)
-
Procapil (olive, citrus, and glycine-histidine-lysine complex)
-
Capilia Longa (turmeric extract)
-
Cressatine (watercress and Indian watercress)
-
Ronacare Biotin Plus (biotin)
These components penetrate the scalp deeply. They promote hair shaft growth, prevent cell aging caused by oxidative stress, rejuvenate the hair bulb, improve blood flow, strengthen hair roots, support keratin production, and encourage longer, healthier hair growth.
Key Findings: Reduced Hair Loss and Improved Hair Health
Patients who used both the Stem Cell Hair Serum and Minoxidil showed significant reductions in hair loss. The average number of hairs lost dropped from 48.10 to 22.68—a greater improvement compared to minoxidil alone (p = 0.0220).
The hair pull test results also favored the combined treatment. The Stem Cell Hair Serum group had a lower mean ranking score (26.97) compared to the minoxidil-only group (34.03), indicating better efficacy (p = 0.0196).
Photographic analysis supported these results. The average improvement score for the Cuticapil group was 36.13, significantly higher than the 24.87 score in the minoxidil group (p = 0.0057). Trichoscopy and blinded photographic reviews confirmed better hair appearance and health in the Cuticapil users.
Importantly, no adverse events or serious side effects were reported, demonstrating the safety and tolerability of the stem cell hair serum.
Study Limitations and Future Directions
The study’s limitations include a relatively small sample size and short follow-up period. These factors may limit how broadly the results apply. The researchers recommend future studies with larger, more diverse patient groups and longer durations, especially including patients with more severe hair loss.
Addressing Minoxidil’s Limitations with Cuticapil
While minoxidil is a common hair loss treatment, it has drawbacks such as incomplete hair regrowth, slow onset, and side effects like hormonal imbalances, scalp irritation, facial hair growth, and dermatitis.
The addition of Cuticapil stem cell hair serum may help overcome these challenges and enhance treatment outcomes.
Need for Safer and More Effective Hair Loss Treatments
The study authors emphasize that current treatments like minoxidil do not fully address the needs of all patients. They call for the development of alternative therapies that are safer and more effective. Botanical ingredients and novel formulations like Cuticapil show promise in targeting the root causes of hair loss and improving overall hair health.
“These deficiencies highlight an unmet treatment gap that requires the exploration of alternative, safer, and more effective options, particularly those that utilize botanicals or novel formulations to address the underlying causes and improve overall hair health,” the researchers concluded.
Related Topics
- Love Island’s Harry Cooksley On His Hair Transplant Journey
- Samantha Bush Shares Her Heartbreaking Hair Loss Story
- Avimee Herbal Unveils Post-COVID Hair Oil
